Statistically, some vocal fold lesions such as vocal fold nodules - considered as a localized tissue reaction to voice loading - are much more frequent in female (~ 95%) than in male (~ 5 %) adult humans. This can only partially be explained by the about two times higher oscillation frequency during voice production in females. In previous studies, gender-related differences in the shape of the vocal fold edge have been observed that can be related to different geometries of the laryngeal framework [1]. With a time-domain model of vocal fold function the oscillation patterns and resulting forces between and inside the vocal folds can be investigated [2] . The aim is to validate the concept of hourglass-shaped vibration pattern, responsible for localised tissue reaction, clinically defined as vocal fold nodules.
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