Design of an ROC study using simulated lesions in whole-body FDG-PET

摘要

The authors propose to use ROC criteria to compare the effect on lesion detectability of OSEM reconstruction, compared with conventional FBP, and the effect of segmented attenuation correction (S-A/C) on lesion detectability in whole-body FDG-PET. This work includes the development of techniques to insert simulated lesions into patient images in a realistic fashion, obviating the need to an intuitive extrapolation from phantom-based results to the clinical setting. The authors explore the issues involved in designing such a study.