Robust estimation of urea concentration during dialytic treatment

摘要

During dialysis it is important to estimate the urea concentration in the patient from measurements available only in the blood. We design a Kalman estimator based on a bicompartmental model of the urea concentration dynamics. In order to deal with the high interpatient variability of the model parameters, a robust design approach has been pursued which optimizes an average performance index. The applicability of other approaches is finally discussed.