Metabolization of ALA Taken Orally and Its Effects on Skin and Tumors

摘要

Objective: Research on the metabolize of ALA (after take orally) on skin and tumor, to find the best dose and diagnostic time of ALA after take orally Methods: Measure the fluorescence spectra of tumor and skin with different dose of ALA take orally ( 20mg/kgx 40mg/kg, 60mg/kg, 80mg/kg, 100mg/kg) and different time after ALA take orally (1h, 2h, 4h, 6h, 8h, 10h, 12h, 24h, 48h) when irradiated by laser. By analyzing the spectrum of fluorescence with optical multi-channel analyzer (OMA), also the fluorescence intensity should be normalized. Result: The best ratio (I_(tumor)/I_(nomal)) of skin was obtained at 60mg/kg, of ALA take orally and 6-8h after ALA take orally Conclusion: Measure the fluorescence spectrum of tumor and skin by using optical multi-channel analyzer (OMA). The best dose was 60mg/kg of ALA take orally and the measure time was 6-8 hours after ALA taking orally.