PREPARATION AND PROPERTIES OF EDIBLE ZEIN-BASED COMPOSITE NANOPARTICLES

摘要

In past decades, more and more proteins are applied to prepare drug delivery carriers as they are generally considered safer than synthetic polymers. Zein is a kind of edible gliadin. Due to its inherent biodegradability and biocompatibility, zein nanoparticles were successfully applied as a carrier for controllable release for drugs and dietary supplements. Owing to the nontoxicity and edibility of CaCO_3, it is used in a wide range of fields. In this paper, an edible Zein/CaCO_3 composite nanoparticles (nanoZCa) has been prepared, and applied to controlling release drug. Adopting solvent-nonsolvent precipitation method, nanoZCa composite nanoparticles were successfully prepared. FT-IR, SEM and DLS were used to characterize ZCa composite nanoparticles. It demonstrates that nanoZCa are near sphere particles, particle size and shape could be controlled by Zein/CaCO_3 mass ratio. And most of particle sizes are from 50-150 nm. Using RB as water-soluble model drug, drug carry and release behaviors of nanoZCa were investigated. Being compared with the zein nanoparticles, the encapsulation efficiency of nanoZCa were enhanced obviously, which got to 75.7%. The release ratio of RB in RB@nanoZCa could be controlled by pH value and the content of CaCO_3. These properties made Zein/CaCO_3 composite nanoparticles become a promising candidate in drug delivery system. The project was supported by the NSFC (No. 21364012, 21263024), PCSIRT (IRT1177) and Res Fund for Postgraduate Tutors in Inst Higher Edu Gansu Prov China(1201-15).