Magnetic Properties of Lewis Lung Carcinoma and Antitumor Magneto-Sensitive Complex

摘要

In this study we have examined endogenous magnetic characteristics of Lewis lung carcinoma of C57BL/6 mice and mechano-magneto-chemical synthesized magneto-sensitive complex (MC) consisted of magnetic nanoparticles Fe_3O_4 with KCI and antitumor antibiotic anthracycline do-xorubicin (DR). Magnetic properties were studied by the method of vibrating magnetometry and electron spin resonance spectroscopy. Lewis lung carcinoma on 14 day after inoculation is weak soft ferromagnetic with saturation magnetic moment m_s = + 0.187 emu/g in contrast to diamagnetic environment tissues (m = - 0.002 emu/g). Lewis lung carcinoma had higher concentration of paramagnetic centers compared to environment tissue. Maximal concentration of paramagnetic centers was observed in MC samples (10~(18) mg~(-1)). The g-factor for MC increased up to 2.64. DR after mechano-magneto-chemical treatment is paramagnetic (m = + 0.068 emu/g at H = 3000 Oe) in contrast to conventional drug which is diamagnetic (m = - 0.200 emu/g).