A PPG sensor for continuous cuffless blood pressure monitoring with self-adaptive signal processing

摘要

A new portable PPG-BP device designed for continuously measuring blood pressure (BP) without a cuff is proposed in this study. This continuous and long-time BP monitoring enabled herein by the proposed portable cuffless BP sensor. Towards the aforementioned goal, the sensor is designed capable of detecting in real time, non-invasively and continuously the temporal intravascular blood volume change based on the principle of photoplethysmograph (PPG) for estimating BP. The hardware of the sensor consists mainly of light emitting diodes (LEDs) in wavelengths of 660 nm, a photo detectors (PD), and also signal processing chips to read output signals of the PD. The PD readout circuit includes a PD pre-amplifier, a band-pass filter, a programmable gain amplifier (PGA), a microcontroller unit for calculation and a wireless module for communication. A laptop is also used to display continuous BPs and conducts statistical analysis and displaying results. 27 subjects participated in the experimental validation, in which the obtained BPs are calibrated by and then compared with the results from a commercial blood pressure monitor by OMRON. The resultant signal-to-noise ratio (SNR) is capable of rising more than 15%, correlation coefficient, R, for systolic blood pressure (SBP) and diastolic blood pressure (DBP) are 0.89 and 0.98, respectively.