首页> 外文会议>IEEE 12th International Conference on Bioinformatics amp; Bioengineering : Final Program amp; Abstract Book. >GIDT #x2014; A tool for the identification and visualization of genomic islands in prokaryotic organisms
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GIDT #x2014; A tool for the identification and visualization of genomic islands in prokaryotic organisms

机译:GIFT —一种用于识别和可视化原核生物中基因组岛的工具

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For decades, it has been a challenge for biologists to identify genomic islands (GIs) within a bacterial genome as they usually rapidly evolve. The purpose of this research is to develop an application which will analyse DNA sequences, enabling researchers to be up-to-date with bacterial evolution. A Java-based GI detection tool, “Genomic Islands Detection Tool (GIDT)" is introduced to detect GI regions by using a number of nucleotide-based statistical methods and genic methods (including GC-content variation, codon usage bias, dinucleotide frequency bias, tetranucleotide frequency bias, and k-mer signature analysis) and identification of mobility genes. It takes as input genome files in embl/genbank — file formats and returns probable GI regions in a tree-view display along with a circular-view display. GIDT is a simple tool which uses six GI identification algorithms and visually displays probable GI regions in a given genome. It runs on Microsoft windows, MacOS and Linux.
机译:几十年来,生物学家要鉴定细菌基因组中的基因组岛(GIs)通常是迅速发展的,这一直是一个挑战。这项研究的目的是开发一种可分析DNA序列的应用程序,使研究人员能够及时了解细菌的进化。引入了基于Java的GI检测工具“基因组孤岛检测工具(GIDT)”,以使用多种基于核苷酸的统计方法和遗传方法(包括GC含量变化,密码子使用偏倚,二核苷酸频率偏倚)来检测GI区域。 ,四核苷酸频率偏向和k-mer签名分析)以及迁移性基因的识别(以embl / genbank)文件格式作为输入基因组文件,并在树视图显示和圆视图显示中返回可能的GI区域。 GIDT是一个简单的工具,它使用六种GI识别算法,并以可视方式显示给定基因组中可能的GI区域,可在Microsoft Windows,MacOS和Linux上运行。

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