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Cascaded microring resonators for biomedical applications: Improved sensitivity at large tuning range

机译:用于生物医学应用的级联微环谐振器:在大调谐范围内提高了灵敏度

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The progress in bioanalytics caused a growing demand of innovation in reliable, miniaturized and low cost optical sensor systems based on integrated optical devices. We present a detailed analysis of sensor elements for applications in aqueous solution based on two cascaded microring resonators (MRRs) by using the Vernier effect (VE). This approach is beneficial for ultra-high sensitivity at large fabrication tolerances, aspects of crucial importance for the practical detection of biomolecules such as peptides. The architecture consists of two silicon nitride microrings connected via a bus waveguide. The free spectral range (FSR) of individual rings is slightly different in order to achieve VE. Thereby the external refractive index of the reference ring is fixed; the second one varies due to the presence of the analyte. The precise operation is controlled by using spectral tuning via integrated micro-heaters. Theoretical analysis has been performed for different structural parameters. A sensitivity several orders of magnitude higher than in the case of a single ring can be predicted for TE and TM polarization, respectively. The first design of Vernier devices and its experimental characterization will be presented. The devices include tapered grating couplers in order to couple light between fibers and chip at moderate alignment tolerances in a reliable manner. Therefore, by combining the VE and the spectral tuning, cascaded MRRs are an optical configuration very promising for sensing applications.
机译:生物分析技术的进步导致对基于集成光学设备的可靠,小型化和低成本光学传感器系统的创新需求不断增长。我们通过使用Vernier效应(VE)对基于两个级联微环谐振器(MRR)的水溶液中的传感器元件进行了详细分析。这种方法有利于在较大的制造公差下实现超高灵敏度,这对于实际检测生物分子(如肽)至关重要。该架构由两个通过总线波导连接的氮化硅微环组成。为了获得VE,各个环的自由光谱范围(FSR)略有不同。由此,基准环的外部折射率固定。第二种因分析物的存在而变化。通过集成的微型加热器使用频谱调谐来控制精确的操作。对不同的结构参数进行了理论分析。对于TE和TM极化,可以分别预测比单个环的情况高几个数量级的灵敏度。将介绍Vernier设备的第一个设计及其实验特性。该设备包括锥形光栅耦合器,以便以可靠的方式以适中的对准公差在光纤和芯片之间耦合光。因此,通过组合VE和频谱调谐,级联MRR是一种非常有希望用于传感应用的光学配置。

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