In vitro testing of osteoinductivity and osteoconductivity of titanium alloys with nanostructured surface for orthopaedic applications

摘要

These preliminary results indicate that the nanotubes with greater diameter possess better osteoinductive and osteoconductive properties. Nevertheless, for further studies, we would like to use more appropriate model (MC3T3-E1 or SaOs cells) and also evaluate parameters such as ability of extracellular matrix formation and mineralisation, which can be studied via monitoring of type I collagen and osteocalcin expression using qPCR. In the next step, newly developed beta-titanium alloys with elastic modulus closer to bone will be studied.