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Fabricating multifunctional microbubbles and nanobubbles for concurrent ultrasound and photoacoustic imaging

机译:制备多功能微气泡和纳米气泡以同时进行超声和光声成像

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Background: Clinical ultrasound (US) uses ultrasonic scattering contrast to characterize subcutaneous anatomic structures. Photoacoustic (PA) imaging detects the functional properties of thick biological tissue with high optical contrast. In the case of image-guided cancer ablation therapy, simultaneous US and PA imaging can be useful for intraoperative assessment of tumor boundaries and ablation margins. In this regard, accurate co-registration between imaging modalities and high sensitivity to cancer cells are important.rnMethods: We synthesized poly-lactic-co-glycolic acid (PLGA) microbubbles (MBs) and nanobubbles (NBs) encapsulating India ink or indocyanine green (ICG). Multiple tumor simulators were fabricated by entrapping ink MBs or NBs at various concentrations in gelatin phantoms for simultaneous US and PA imaging. MBs and NBs were also conjugated with CC49 antibody to target TAG-72, a human glycoprotein complex expressed in many epithelial-derived cancers.rnResults: Accurate co-registration and intensity correlation were observed in US and PA images of MB and NB tumor simulators. MBs and NBs conjugating with CC49 effectively bound with over-expressed TAG-72 in LS174T colon cancer cell cultures. ICG was also encapsulated in MBs and NBs for the potential to integrate US, PA, and fluorescence imaging.rnConclusions: Multifunctional MBs and NBs can be potentially used as a general contrast agent for multimodal intraoperative imaging of tumor boundaries and therapeutic margins.
机译:背景:临床超声(美国)使用超声散射对比来表征皮下解剖结构。光声(PA)成像可检测具有高光学对比度的厚生物组织的功能特性。在以图像为指导的癌症消融治疗的情况下,同时进行US和PA成像可在术中评估肿瘤边界和消融余量。在这方面,成像方式与对癌细胞的高敏感性之间的准确共配准很重要。rn方法:我们合成了封装有印度墨水或吲哚菁绿的聚乳酸-乙醇酸微囊泡(MBGA)和纳米囊泡(NBs)。 (ICG)。通过将明胶体模中不同浓度的墨水MB或NB捕获以同时进行US和PA成像,可以制造出多个肿瘤模拟器。 MBs和NBs也与CC49抗体结合,靶向TAG-72,TAG-72是在许多上皮来源的癌症中表达的人糖蛋白复合物。与CC49结合的MB和NB与LS174T结肠癌细胞培养物中过表达的TAG-72有效结合。 ICG还被封装在MBs和NBs中,具有整合US,PA和荧光成像的潜力。结论:多功能MBs和NBs可以潜在地用作肿瘤边界和治疗边界的多模式术中成像的一般造影剂。

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