A Bioadhesive Nanoparticle Formulation for Improved Oral Delivery of Paclitaxel

摘要

A bioadhesive, polymer-based paclitaxel formulation,and control formulations of stock paclitaxel and a nonbioadhesive,polymer-based paclitaxel formulation weremanufactured and administered to separate cohorts of rats.Plasma samples were obtained at specified times,analyzed by HPLC, and pharmacokinetic profiles weredetermined. A marked increase in paclitaxel area underthe curve (AUC) was observed in the Pk profile of thebioadhesive formulation group compared to that of thestock drug and non-bioadhesive formulation groups. Thisimprovement over stock drug and non-bioadhesiveformulations was attributed to bioadhesive particle uptakeand subsequent paclitaxel release from the particles.