Micronized Insulin Generation By Supercritical Antisolvent PrecipitationFor Pulmonary Delivery

机译：超临界反溶剂沉淀法生产的微粉化胰岛素

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Micronized insulin particles were generated byrnSupercritical antisolvent precipitation technology. Thernprocess variables were optimized and insulinrnmicroparticles were characterized. In vitro-in vivornevaluation of microparticles indicated that model proteinrninsulin retained its stability and biological activity afterrnsupercritical fluids treatment. Resultant product hasrnpotential of incorporation in pulmonary delivery systems.

机译：超临界反溶剂沉淀技术产生了微粉化的胰岛素颗粒。优化了过程变量并表征了胰岛素微粒。微粒的体外-体内评价表明，模型蛋白胰岛素在超临界流体处理后仍保持其稳定性和生物活性。最终产品具有掺入肺部输送系统的潜力。

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来源
《Controlled Release Society 31st annual meeting transactions: abstracts》|2004年|1-2|共2页
会议地点 Honolulu HI(US)
作者
Aruna Khanolkar; Amrita Bajaj; Madhumanjiri Gatane; Pragati Pandit;
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作者单位

C.U.Shah College Of Pharmacy, S.N.D.T. University, Santacruz, Mumbai, India aruna_ask@yahoo.com;

C.U.Shah College Of Pharmacy, S.N.D.T. University, Santacruz, Mumbai, India;

Bombay Veterinary College, Parel, Mumbai, India;

C.U.Shah College Of Pharmacy, S.N.D.T. University, Santacruz, Mumbai, India;

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原文格式 PDF
正文语种 eng
中图分类
关键词
Insulin; Microparticles; Protein stability; rnSuper critical fluids; Pulmonary delivery;

机译：胰岛素;微粒；蛋白质稳定性;超临界流体;肺部输送;

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专利

1. Micronization of insulin from halogenated alcohol solution using supercritical carbon dioxide as an antisolvent. [J] . Snavely WK, Subramaniam B, Rajewski RA, Journal of pharmaceutical sciences. . 2002,第9期

机译：使用超临界二氧化碳作为抗溶剂，从卤化醇溶液中将胰岛素微粉化。
2. Preparation of 5-fluorouracil nanoparticles by supercritical antisolvents for pulmonary delivery [J] . Pardis Kalantarian, Abdolhosein Rouholamini Najafabadi, Ismaeil Haririan, International Journal of Nanomedicine . 2010,第Supplementa1期

机译：用超临界抗溶剂制备5-氟尿嘧啶纳米颗粒用于肺部递送
3. Generation of quercetin/cellulose acetate phthalate systems for delivery by supercritical antisolvent process [J] . Garcia-Casas I., Montes A., Pereyra C., European journal of pharmaceutical sciences . 2017,第期

机译：通过超临界抗溶解方法产生槲皮素/醋酸醋酸纤维素体系
4. Micronized Insulin Generation By Supercritical Antisolvent Precipitation For Pulmonary Delivery [C] . Controlled Release Society annual meeting . 2004

机译：通过超临界抗溶解沉淀来肺递送的微粉化胰岛素
5. Micronization of insulin from halogenated alcohol solution using supercritical carbon dioxide as antisolvent. [D] . Snavely, William Kirk. 2001

机译：使用超临界二氧化碳作为抗溶剂，从卤代醇溶液中将胰岛素微粉化。
6. Preparation of 5-fluorouracil nanoparticles by supercritical antisolvents for pulmonary delivery [O] . Pardis Kalantarian, Abdolhosein Rouholamini Najafabadi, Ismaeil Haririan, 2010

机译：超临界抗溶剂制备5-氟尿嘧啶纳米颗粒用于肺部递送
7. Preparation of 5-fluorouracil nanoparticles by supercritical antisolvents for pulmonary delivery [O] . Kalantarian, Pardis, Najafabadi, Abdolhosein Rouholamini, Haririan, Ismaeil, 2010

机译：超临界抗溶剂制备5-氟尿嘧啶纳米颗粒用于肺部递送

Micronized Insulin Generation By Supercritical Antisolvent PrecipitationFor Pulmonary Delivery

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