Fabrication and Characterization of Bioactive Composite Scaffolds Based on β-TCP-BG-PLA for Bone Tissue Engineering

摘要

In this study, the bioactive composites based on β-tricalcium phosphate (P-TCP), bioglass (BG) and poly lactic acid (PLA) were prepared. The microstructure, degradability and reaction products of the scaffold soaked in a simulated body fluid (SBF) at 36.5℃ for different days were characterized through scanning electron microscopy (SEM), energy-dispersive X-ray analysis (EDS), X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FT-IR) and induced coupled plasma spectroscopy (ICP). The weight loss and strength decrease with the time were tested. The results showed that at the same porosity, the degradability of the scaffold samples decreased as followed: β-TCP/BG/PLA ＞β — TCP/BG ＞β — TCP.The materials had highly bioactive response ability to the Simulate Body Fluid (SBF) and promptly induced a bone like HA layer on the surface of the scaffolds when immersed in the SBF.