Novel Chiral Template for Preparation of α-Amino Acids: Practical Synthesis and Application

摘要

A novel chiral imidazolidinone-type template for synthesizing optically active α-amino acids has been developed. The template was prepared from a-phenylethylamine as a chiral source, 2-chloroacetamide, and 2,6-dichlorobenzaldehyde in 4 steps. The process includes crystallization-induced dynamic resolution (CIDR). The template reacted with electrophiles in a highly stereoselective manner under mild conditions to afford alkylated products that were further transformed in 2 steps into optically active a-amino acids.