Towards Argument-Driven Validation of an in silico Model of Immune Tissue Organogenesis

摘要

Computer simulation is a powerful experimental tool that has not previously been exploited when seeking to understand the role of mechanisms involved in lymphoid tissue development. Through integrating this technique with traditional biological experimentation we have developed a baseline model which, through consultation with domain experts, we believed to be an accurate representation of the domain to be modelled. As we have discussed, the behaviour which emerges from the simulation does not faithfully replicate that seen experimentally.