Mathematical Modeling of a Tunable Drug Delivery Platform Based on High Affinity Molecular Interactions

摘要

Mathematical modeling plays an important role in the design of biomaterials for tissue engineering and drug delivery by identifying key release mechanisms and parameters. Our group has developed a model for an affinity-based drug delivery system (DDS) using |3-cyclodextrin, which can be tuned to offer different release profiles. This could be particularly useful for increasing the therapeutic lifetime of drug delivery implants and limiting the need for multiple implants. In this research we explore the transport processes underlying the loading and release of drug from our DDS. Key parameters that affect the loading and release kinetics are identified and estimated. Computer simulations are compared to experimental data to evaluate our model's validity.