Formulation and optimization of Gastric floating matrix tablets of norfloxacin with combination of polymers using Box-Behnken experimental design

摘要

The purpose of the present study was to develop and optimize gastric floating drug delivery system (GFDDS) containing norfloxacin as a model drug using Box-Behnken design. A 3-factor, 3-level Box-Behnken design was used to derive a second order polynomial equation and construct contour plots to predict responses. The independent variables selected were Compritol ATO 888 (X_1), Poloxamer 188 (X_2) and chitosan (X_3). Fifteen batches were prepared by wet granulation method and evaluated for Floating lag time (FLT), total floating time (TFT) and time required to release 50% of the drug (t_(50)) as dependent variables. Compritol ATO 888 containing tablets were found to be significant for floating properties, poloxamer 188 had a negative effect on floating properties but was found helpful in controlling the release rate of the drug. No significant effect of chitosan on floating properties was observed but it was important for gel formation. The computer optimization process and contour plots predicted the levels of independent variables X_1, X_2, and X_3 (26.33, 9.20 and 15.13 respectively), for maximized response of TFT.