Antiplasmodial Activity of Twenty Essential Oils from Malagasy Aromatic Plants

摘要

In search for new plant-derived biologically active compounds against malaria parasites resistant to commercially available drugs, twenty essential oils extracted from Malagasy aromatic plants were assessed for their anti-plasmodial activity against the multi-drug-resistant strain of Plasmodium falciparum FCM29. The plants were subjected to steam distillation and the aromatic volatile oils captured using a Clevenger trap. Fourteen essential oils were active against Plasmodium falciparum in culture with IC50s ranging from 27-225 μg/mL. While the essential oils (Cymbopogon citratus and Lantana camara) showed activities similar to that of chloroquine, none exhibited the high activity as achieved by quinine.