首页> 外文会议>The 6'th International Forum on Post-genome Technologies(6'IFPT)(第六届国际后基因组生命科学技术学术论坛) >THE EFFECTS OF REPETITVE TRANSCRANIAL MAGNETIC STIMULATION ON THE EXPRESSIONS OF BDNF, NMDAR1, SYN IN HIPPOCAMPAL CA1 AREA OF RATS MODEL WITH VASCULAR DEMENTIA
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THE EFFECTS OF REPETITVE TRANSCRANIAL MAGNETIC STIMULATION ON THE EXPRESSIONS OF BDNF, NMDAR1, SYN IN HIPPOCAMPAL CA1 AREA OF RATS MODEL WITH VASCULAR DEMENTIA

机译:重复性经颅磁刺激对血管性痴呆模型大鼠海马CA1区BDNF,NMDAR1,SYN表达的影响

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Purpose To study the effects of rTMS on the expression of BDNF, NMDAR1 and SYN in hippocampal CA1 area of rats model with VaD, and to further explore the molecular mechanism of the rTMS treatment on vascular dementia. Methods Rats were randomly divided into four groups. Low-frequency stimulation group rats were accepted 0. 5Hz rTMS for six weeks. High-frequency stimulation group rats were accepted 5Hz rTMS for six weeks. The expression of BDNF, NMDAR1 and SYN in hippocampal CA1 area were detected by immunohistochemistry. Results The expressions of BDNF, NMDAR1 and SYN protein in the stimulation groups were higher than that in the dementia model group (P<0. 05). Conclusion rTMS had a role in the restoration treatment of vascular dementia, which may be related to the mechanism that rTMS can increase the expressions of BDNF, NMDAR1 and SYN, and affect the synaptic plasticity in hippocampal CA1 area of the VaD rats.
机译:目的研究rTMS对VaD大鼠模型海马CA1区BDNF,NMDAR1和SYN表达的影响,并进一步探讨rTMS治疗血管性痴呆的分子机制。方法将大鼠随机分为四组。低频刺激组大鼠接受0. 5Hz rTMS,持续六周。高频刺激组大鼠接受5Hz rTMS,持续6周。免疫组化检测BDNF,NMDAR1和SYN在海马CA1区的表达。结果刺激组BDNF,NMDAR1和SYN蛋白的表达高于痴呆模型组(P <0。05)。结论rTMS在血管性痴呆的修复中起一定作用,可能与rTMS增加BDNF,NMDAR1和SYN的表达,影响VaD大鼠海马CA1区突触可塑性有关。

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