Identification of differentially methylated regions (DMRs) by entropy

摘要

@@1.Introduction DNA methylation, as an inartificial and inheritance epigenetic event, affects biological phenotype by inhibiting gene expression without changing the DNA sequence. The quantification of methylation difference across large numbers of samples and the identification of sample-specificity are important in genomic function analysis, and may provide an important reference for identifying specific drug targets. Differentially methylated regions (DMRs), as regions with diversity of methylation patterns, are regarded as possible functional regions in gene