A First Look at the Co-evolution Modules in Drosophila Genome

摘要

@@The prediction of protein-protein interaction (PPI) has become a major issue of bioinformatics, and many methodologies were developed to accurately predict PPI using sequences data, gene expression data et al. Pazos and Valencia proposed a PPI prediction method using protein evolution information called Mirror Tree Method (MT Method) in 2001. It assumed that PPI is a key determinant of molecular function thus can constrain the genetic mutation of both interacting proteins. It calculated and compared the co-evolution index of interacting and noninteracting protein pairs by construction of phylogenetic trees and calculation of distance matrices in different organisms. The co-evolution index was defined as the Pearson's correlation of two distance matrixes of two proteins. Since it has been well known that proteins work together to form functional modules and pathways in vivo, it is reasonable to raise the assumption that the coevolution phenomenon may also happen in modules and pathways.