首页> 外文会议>3rd International EMF Seminar in China: Electromagnetic Fields and Biological Effects; Oct 13-17, 2003; Guilin, China >EXPERIMENT STUDY OF CD31 REDISTRIBUTION, EXPRESSION AND PHOSPHORYLATION IN ENDOTHELIAL CELLS POST MICROWAVE IRRADIATION
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EXPERIMENT STUDY OF CD31 REDISTRIBUTION, EXPRESSION AND PHOSPHORYLATION IN ENDOTHELIAL CELLS POST MICROWAVE IRRADIATION

机译:微波辐照后内皮细胞中CD31重新分布,表达和磷酸化的实验研究

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摘要

These findings suggest: (1) Microwave irradiation causes phosphorylation of CD31 that may have effect of signal transduction and induce changes in biological behavior of proteins related to vascular barrier. Inhibition phosphorylation of CD31 has some effect to protect blood vessel permeability from damage caused by microwave. (2)Redistribution of CD31 caused by radiation influences the cell shape and cell adhesion junction, it becomes the structural basis of leukocyte infiltration and permeability dysfunction. (3) Upregulation expression of CD31 mRNA and protein induced by irradiation provide a precondition for leukocyte to interact with endothelial cells and directly influence the transendothelial migration of leukocyte. Antibody against to CD31 could inhibit transmigration of monocyte like HL-60 on endothelial cells induced by microwave significantly.
机译:这些发现表明:(1)微波辐射导致CD31磷酸化,可能具有信号转导作用,并诱导与血管屏障有关的蛋白质生物学行为发生变化。 CD31的抑制磷酸化具有一定的作用,可以保护血管的通透性免受微波的损害。 (2)辐射引起的CD31重新分布影响细胞形态和细胞黏附连接,成为白细胞浸润和通透性障碍的结构基础。 (3)辐射诱导的CD31 mRNA和蛋白表达上调为白细胞与内皮细胞相互作用,直接影响白细胞跨内皮迁移提供了前提。抗CD31抗体可显着抑制微波诱导的HL-60等单核细胞向内皮细胞的迁移。

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