首页> 外文会议>International EMF seminar in China: Electromagnetic fields and biological effects >EXPERIMENT STUDY OF CD31 REDISTRIBUTION, EXPRESSION AND PHOSPHORYLATION IN ENDOTHELIAL CELLS POST MICROWAVE IRRADIATION
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EXPERIMENT STUDY OF CD31 REDISTRIBUTION, EXPRESSION AND PHOSPHORYLATION IN ENDOTHELIAL CELLS POST MICROWAVE IRRADIATION

机译:微波辐射后内皮细胞中CD31再分配,表达和磷酸化的实验研究

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These findings suggest: (1) Microwave irradiation causes phosphorylation of CD31 that may have effect of signal transduction and induce changes in biological behavior of proteins related to vascular barrier. Inhibition phosphorylation of CD31 has some effect to protect blood vessel permeability from damage caused by microwave. (2)Redistribution of CD31 caused by radiation influences the cell shape and cell adhesion junction, it becomes the structural basis of leukocyte infiltration and permeability dysfunction. (3) Upregulation expression of CD31 mRNA and protein induced by irradiation provide a precondition for leukocyte to interact with endothelial cells and directly influence the transendothelial migration of leukocyte. Antibody against to CD31 could inhibit transmigration of monocyte like HL-60 on endothelial cells induced by microwave significantly.
机译:这些发现表明:(1)微波辐射导致CD31的磷酸化,这可能具有信号转导的效果,并诱导与血管屏障有关的蛋白质生物行为的变化。 CD31的抑制磷酸化具有一些效果,以保护血管渗透性免受微波引起的损伤。 (2)通过辐射引起的CD31再分布影响细胞形状和细胞粘附结,它成为白细胞浸润和渗透性功能障碍的结构基础。 (3)辐射诱导CD31 mRNA和蛋白的上调表达为白细胞与内皮细胞相互作用,直接影响白细胞的颅骨迁移。反对CD31的抗体可以抑制单核细胞的迁移,如HL-60显着诱导的内皮细胞。

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