Automated Sedation using propofol and midazolam based on Bispectral Index for ICU patients

摘要

In this paper we present an automated sedation system for ICU setting. The system is based on objective sedation assessment using the bispectral index and takes into account the patient's hemodynamics i.e. heart rate and blood pressure to ensure that the target sedation level is reached safely. Two different intravenous sedative agents are used (propofol and midazolam) in two separate algorithms for closed loop automated sedation. Different sedation scenarios are simulated in order to mimic this medical process and test for possible complications that the patient might face during the stay in the ICU. The proposed system is adaptable to patient hemodynamic variations and presents an automated process to achieve an optimal target sedation. This system could reduce the patient's ICU length of stay, facilitates the work of the ICU nurses.