Rapid Detection of Multiple Myeloma using a microfluidic platform

摘要

Diagnosis platforms incorporating microfluidic chips enable sensitive, rapid and accurate genetic analysis at low cost that could facilitate customized therapies tailored to match the vulnerabilities of each individual cancer clone. Multiple Myeloma (MM) is characterized by a distinct immunoglobulin gene rearrangement, and by IgH translocations that enable unequivocal identification of the MM clone. Here, microfluidic chip based approaches for genetic amplification via PCR and chip-based electrophoretic detection is demonstrated. Further development of the microfluidic platform could facilitate monitoring of response to therapy, detection of residual cancer cells that lead to relapse and potential prognostic capabilities in myeloma.