The introduction of a trifluromethyl group (CF3) into organic molecules can result in profound changes of the biological activities of these molecules.In contrast to the tremendous progress that has been made toward the direct introduction of a trifluoromethylgroup into organic compounds,the chemistry of 2,2,2-trifluoroethyl carbanions (CH2CF3)has remained undeveloped despite their potential usefulness.The 2,2,2-trifluoroethyl phenyl sulfone (PhSO2CH2CF3) is a simple and easily available organic compounds,and thephenylsulfone group may stabilizes the trifluoroethyl carbanion. Under neutral conditions,by using Pd(PPh3)4 as catalyst, the allylation reaction of 2,2,2-trifluoroethyl phenyl sulfone withvariety allylic carbonates proceeded smoothly.The trifluoroethyl moiety has been introduced onto the allylic position without the release of fluoride.
展开▼
