The present invention relates to a composition for skin improvement comprising an umbilical cord (umbilical cord)-derived mesenchymal stem cell culture medium as an active ingredient, and a pharmaceutical composition for preventing or treating inflammatory skin diseases, wound relief, wrinkle improvement, regeneration, elasticity increase, moisturizing, Since it exhibits barrier strengthening, anti-inflammatory or antioxidant effects, it will be usefully used as a cosmetic composition for skin improvement or prevention of inflammatory skin disease or a pharmaceutical composition.
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