Method for producing mesodermal cells and / or vascular endothelial colony forming cell like cells having angiogenic ability in vivo

摘要

Problem to be solved: to provide a method capable of obtaining ECFC or other types of cells which can be used for vascular repair.In vitro, we provide a method for differentiating pluripotent stem cells into KDR + NCAM + aplnr + mesoderm cells and / or ssea5-kdr + NCAM + aplnr + mesoderm cells.The mesodermal cells disclosed in the present application may be used to form blood vessels in vivo and / or in vitro may create vascular endothelial colony forming cell like cells (ECFCs like cells).It also provides purified human KDR + NCAM + aplnr + mesoderm cell populations and purified human ECFC like cell populations.Further, a method and a method of screening a test drug using a cell population of the present disclosure are provided.No selection