Phamaceutical composition for preventing or treating non small cell lung cancer comprising evodiamine as an active ingredient

摘要

The present invention relates to a composition for preventing or treating non-small cell lung cancer comprising evodiamine as an active ingredient. The composition comprising evodiamine of the present invention as an active ingredient inhibits tumor growth, inhibits HSP70 protein expression and spheroid formation ability of cancer stem cells, and tumors in cancer cell line xenografts and patient-derived cancer xenograft mouse models In addition to inhibiting the growth of cancer cells, it has a synergistic effect when combined with drugs such as pemetrexed, cisplatin, and paclitaxel, and has anticancer effects on drug-resistant cancer cells, so it is widely used in the prevention and treatment of non-small cell lung cancer It is expected that it will be possible.