PHARMACEUTICAL COMPOSITION COMPRISING EVODIAMINE AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF NON-SMALL CELL LUNG CANCER

摘要

The present invention relates to a composition comprising evodiamine as an active ingredient for prevention or treatment of non-small cell lung cancer. The composition comprising evodiamine as an active ingredient according to the present invention not only inhibits tumor growth, HSP70 protein expression, the ability of cancer stem cells to form spheroids, and the growth of tumors in cancer cell line xeno-transplanted, and patient-derived cancer xeno-transplanted mouse models, but also exhibits an anticancer efficacy against cancer cells resistant to drugs in synergy with a drug, such as pemetrexed, cisplatin, and paclitaxel when used in combination, and as such, is expected to find a broad range of applications in preventing and treating non-small cell lung cancer.