NOVEL CORONAVIRUS VACCINE CONSTRUCTION METHOD AND USE THEREOF

摘要

Provided is a novel coronavirus vaccine construction method and a use thereof, comprising: (a) carrying out amino acid substitution on a wild-type novel coronavirus S protein receptor binding domain to obtain a candidate S-RBD sequence, wherein the candidate S-RBD sequence has a lower isoelectric point than the wild-type novel coronavirus S protein receptor binding domain; (b) determining a target S-RBD sequence based on the candidate S-RBD sequence and the three-dimensional structure of the wild-type novel coronavirus S protein receptor binding domain; and (c) constructing the novel coronavirus vaccine based on the target S-RBD sequence.