Combination of diacylglycerol acyltransferase 2 inhibitor and acetyl-CoA carboxylase inhibitor

摘要

PROBLEM TO BE SOLVED: To provide a pharmaceutically active substance having DGAT2 inhibitory activity and useful in treating, preventing or reducing signs thereof. Described herein are 2- {5-[(3-ethoxypyridine-2-yl) oxy] pyridine-3-yl for the treatment of liver disease and related disorders. } -N-[(3S, 5S) -5-fluoropiperidine-3-yl] pyrimidine-5-carboxamide or a pharmaceutical composition comprising a pharmaceutically acceptable salt thereof. 2- {5-[(3-ethoxypyridine-2-yl) oxy] pyridin-3-yl} -N-[(3S, 5S) -5-fluoro for the treatment of liver disease and related diseases Piperidine-3-yl] pyrimidin-5-carboxamide or a pharmaceutically acceptable salt thereof and 4- (4- (1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro [indazole-5, 5) Compositions comprising 4'-piperidine] -1'-carbonyl) -6-methoxypyridin-2-yl) benzoic acid or a pharmaceutically acceptable salt thereof are also described.