首页> 外国专利> ENGINEERED DYSBIOSIS-SENSING PROBIOTIC FOR CLOSTRIDIUM DIFFICILE INFECTIONS AND RECURRING INFECTIONS MANAGEMENT

ENGINEERED DYSBIOSIS-SENSING PROBIOTIC FOR CLOSTRIDIUM DIFFICILE INFECTIONS AND RECURRING INFECTIONS MANAGEMENT

机译：用于艰难梭菌感染和复发性感染管理的工程化失调敏感益生菌

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摘要

The present invention relates to methods of metabolic engineering bacteria cells to produce bile salt hydrolase to inhibit the germination of C. difficile endospores and colonisation within the human gastrointestinal tract. The bile salt hydrolase is operably linked to a sialic acid-inducible promoter, pNanA, of which pNanA is in turn controlled by the repressor nanR. The recombinant bacteria expressing the bile salt hydrolase can be a probiotic strain to be used for prophylaxis or treatment of C. difficile infection.

机译：本发明涉及代谢工程细菌细胞产生胆盐水解酶以抑制艰难梭菌内孢子萌发和在人类胃肠道内定植的方法。胆盐水解酶可操作地与唾液酸诱导启动子pNanA连接，pNanA由阻遏子nanR控制。表达胆盐水解酶的重组细菌可以是用于预防或治疗艰难梭菌感染的益生菌菌株。

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公开/公告号US2022106603A1

专利类型
公开/公告日2022-04-07

原文格式PDF
申请/专利权人 NATIONAL UNIVERSITY OF SINGAPORE;
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申请/专利号US202017599998
发明设计人 ELVIN KOH;IN YOUNG HWANG;MATTHEW WOOK CHANG;
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申请日2020-04-02
分类号C12N15/75;A61K45/06;C12N15/11;C12N1/20;A61K35/742;A61K35/747;A61P31/04;
国家 US
入库时间 2024-06-14 22:56:03

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