首页> 外国专利> COMPOSITION FOR PREVENTING OR TREATING OBESITY OR DIABETES COMPRISING EXTRACT OF ACANTHOPANAX AND EXTRACT OF GARCINIA CAMBOGIA OR COMPOUNDS ISOLATED THEREFROM

COMPOSITION FOR PREVENTING OR TREATING OBESITY OR DIABETES COMPRISING EXTRACT OF ACANTHOPANAX AND EXTRACT OF GARCINIA CAMBOGIA OR COMPOUNDS ISOLATED THEREFROM

机译：用于预防或治疗肥胖或糖尿病的组合物，其包含刺五加提取物和藤黄提取物或从中分离的化合物

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摘要

The present invention relates to a pharmaceutical composition for the prevention or treatment of obesity or diabetes, and a food composition and feed composition for preventing or improving obesity or diabetes, which include an extract of Oghalpi, Garcinia cambogia, or a compound isolated therefrom as an active ingredient. The composition has synergy (synergy) antidiabetic and antiobesity activity compared to the case of using the ogalpi extract, garcinia cambogia extract, or a compound isolated therefrom. Therefore, it is possible to reduce the possibility of any side effects that may be caused by an overdose or long-term administration of the Garcinia cambogia extract and a substance isolated therefrom, and thus it can be very usefully utilized in the development of a therapeutic agent for diabetes or obesity.

机译：本发明涉及一种用于预防或治疗肥胖症或糖尿病的药物组合物，以及一种用于预防或改善肥胖症或糖尿病的食品组合物和饲料组合物，其包括奥格尔皮提取物、藤黄提取物或从中分离出的化合物作为活性成分。与使用小甘蓝提取物、藤黄提取物或从中分离的化合物相比，该组合物具有协同（协同）抗糖尿病和抗肥胖活性。因此，可以减少因服用过量或长期服用藤黄提取物和从中分离出的物质而引起的任何副作用的可能性，因此它可以非常有效地用于开发治疗糖尿病或肥胖症的药物。

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公开/公告号KR20220030874A

专利类型
公开/公告日2022-03-11

原文格式PDF
申请/专利权人 한국생명공학연구원;
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申请/专利号KR1020210075749
发明设计人 이수의;류형원;김문옥;오세량;김두영;장현재;
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申请日2021-06-10
分类号A61K36/254;A23K10/30;A23K20/105;A23K20/126;A23L33/105;A61K31/191;A61K31/365;A61K36/38;A61P3/04;A61P3/10;
国家 KR
入库时间 2022-08-25 00:06:19

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2. Larvicidal efficacy of plant extracts and isolated compounds from Annonaceae and Piperaceae against Aedes aegypti and Aedes albopictus [J] . Alzeir M. Rodrigues, Victor Emanuel P. Martins, Selene M. Morais 亚太热带医药杂志（英文版） . 2020,第009期

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4. Toxicity of chemical compounds of anorexic action extracted from Garcinia cambogia (garcinia) and Panax ginseng (ginseng) [J] . Carvalho Menezes Camila, Mousinho Lorenna, Peron Ana Paula, Revista Cubana de plantas medicinales . 2014,第4期

5. Effect of herbal combination of triphala and Garcinia cambogia extracts on liver function test and kidney function test in high fat diet induced obesity in rats [J] . Vijay Kumar A. N., Vijay Thawani, Lal Hingorani International Journal of Basic & Clinical Pharmacology . 2019,第12期

6. Toxicity Assay of Phenolic Compound Isolated from the Dichloromethane Extract of Silver Fern (Pityrogramma calomelanos) [C] . Najihah, Suyatno Sutoyo, Ismono, National Seminar on Chemistry . 2018

7. Creation of a computational pipeline to extract genes from quantitative trait loci for diabetes and obesity [D] . Fox, Joseph F. 2015

8. A mixture of the aqueous extract of Garcinia cambogia soy peptide and l-carnitine reduces the accumulation of visceral fat mass in rats rendered obese by a high fat diet [O] . Yun Jung Kim, Keun-Young Kim, Min Sun Kim, 2008

9. Poster session 2Morphogenetic mechanisms290MiR-133 regulates retinoic acid pathway during early cardiac chamber specification291Bmp2 regulates atrial differentiation through miR-130 during early heart looping formationDevelopmental genetics294Association of deletion allele of insertion/deletion polymorphism in alpha 2B adrenoceptor gene and hypertension with or without type 2 diabetes mellitus295Association of G1359A polymorphism of the endocannabinoid type 1 receptor (CNR1) with coronary artery disease (CAD) with type 2 diabetes mellitusCell growth, differentiation and stem cells - Vascular298Gamma-secretase inhibitor prevents proliferation and migration of ductus arteriosus smooth muscle cells: a role of Notch signaling in postnatal closure of ductus arteriosus299Mesenchymal stromal-like cells (MLCs) derived from induced pluripotent stem (iPS) cells: a promising therapeutic option to promote neovascularization300Sonic Hedgehog promotes mesenchymal stem cell differentiation to vascular smooth muscle cells in cardiovacsular disease301Proinflammatory cytokine secretion and epigenetic modification in endothelial cells treated LPS-GinfivalisCell death and apoptosis - Vascular304Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipidsTranscriptional control and RNA species - Vascular307MicroRNA-34a role in vascular calcification308Local delivery of a miR-146a inhibitor utilizing a clinically applicable approach attenuates neointima formation after vascular injury309Long noncoding RNA landscape of hypoxic endothelial cells310Specific circulating microRNAs levels associate with hypertension, hyperglycemia and dysfunctional HDL in acute coronary syndrome patientsCytokines and cellular inflammation - Vascular313Phosphodiesterase5A up-regulation in vascular endothelium under pro-inflammatory conditions: a newly disclosed anti-inflammatory activity for the omega-3polyunsaturated aatty acid docosahexaenoic acid314Cardiovascular risk modifying with extra-low dose anticytokine drugs in rhematoid arthritis315Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation316Lymphocytic myocarditis coincides with increased plaque inflammation and plaque hemorrhage in coronary arteries, facilitating myocardial infarction317Serum osteoprotegerin level predictsdeclined numerous of circulating endothelial- derived and mononuclear-derived progenitor cells in patients with metabolic syndromeGrowth factors and neurohormones - Vascular320Effect of gastrin-releasing peptide (GRP) on vascular inflammationSignal transduction - Heart323A new synthetic peptide regulates hypertrophy in vitro through means of the inhibition of nfkb324Inducible fibroblast-specific knockout of p38 alpha map kinase is cardioprotective in a mouse model of isoproterenol-induced cardiac hypertrophy325Regulation of beta-adrenoceptor-evoked inotropic responses by inhibitory G protein, adenylyl cyclase isoforms 5 and 6 and phosphodiesterases326Binding to RGS3 and stimulation of M2 muscarinic acetylcholine receptors modulates the substrate specificity of p190RhoGAP in cardiac myocytes327Cardiac regulation of post-translational modifications, parylation and deacetylation in LMNA dilated cardiomyopathy mouse model328Beta-adrenergic regulation of the b56delta/pp2a holoenzyme in cardiac myocytes through b56delta phosphorylation at serine 573Nitric oxide and reactive oxygen species - Vascular331Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1 and eNOS332Antioxidant therapy prevents oxidative stress-induced endothelial dysfunction and Enhances Wound Healing333Morphological and biochemical characterization of red blood cell in coronary artery diseaseCytoskeleton and mechanotransduction - Heart336Novel myosin activator, JSH compounds, increased myocardial contractility without chronotropic effect in ratsExtracellular matrix and fibrosis - Vascular339Ablation of Toll-like receptor 9 causes cardiac rupture after myocardial infarction by attenuating proliferation and differentiation of cardiac fibroblasts340Altered vascular remodeling in the mouse hind limb ischemia model in Factor VII activating protease (FSAP) deficiencyVasculogenesis, angiogenesis and arteriogenesis343Pro-angiogenic effects of proly-hydroxylase inhibitors and their potential for use in a novel strategy of therapeutic angiogenesis for coronary total occlusion344Nrf2 drives angiogenesis in transcription-independent manner: new function of the master regulator of oxidative stress response345Angiogenic gene therapy, despite efficient vascular growth, is not able to improve muscle function in normoxic or chronically ischemic rabbit hindlimbs -role of capillary arterialization and shunting346Effect of PAR-1 inhibition on collateral vessel growth in the murine hind limb model347Quaking is a key regulator of endothelial cell differentiation, neovascularization and angiogenesis348"Emerging angiogenesis" in the chick chorioallantoic membrane (CAM). 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focus on the nitric oxide pathwayAging395Heart failure with preserved ejection fraction develops when feeding western diet to senescence-accelerated mice396Cardiovascular markers as predictors of cognitive decline in elderly hypertensive patients397Changes in connexin43 in old rats with volume overload chronic heart failureGenetics and epigenetics400Calcium content in the aortic valve is associated with 1G>2G matrix metalloproteinase 1 polymorphism401Neuropeptide receptor gene s (NPSR1) polymorphism and sleep disturbances402Endothelin-1 gene Lys198Asn polymorphism in men with essential hypertension complicated and uncomplicated with chronic heart failure403Association of common polymorphisms of the lipoprotein lipase and pon1 genes with the metabolic syndrome in a sample of community participantsGenomics, proteomics, metabolomics, lipidomics and glycomics405Gene expression quantification using multiplexed color-coded probe pairs to determine RNA content in sporadic cardiac myxoma406Large-scale phosphorylation study of the type 2 diabetic heart subjected to ischemia / reperfusion injury407Transcriptome-based identification of new anti-inflammatory properties of the olive oil hydroxytyrosol in vascular endothelial cell under basal and proinflammatory conditions408Gene polymorphisms combinations and risk of myocardial infarctionComputer modelling, bioinformatics and big data411Comparison of the repolarization reserve in three state-of-the-art models of the human ventricular action potentialMetabolism, diabetes mellitus and obesity414Endothelial monocyte-activating polypeptide-II improves heart function in type -I Diabetes mellitus415Admission glucose level is independent predictor of impaired left ventricular function in patients with acute myocardial infarction: a two dimensional speckle-tracking echocardiography study416Association between biochemical markers of lipid profile and inflammatory reaction and stiffness of the vascular wall in hypertensive patients with abdominal obesity417Multiple common co-morbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress and myocardial stiffening418Investigating the cardiovascular effects of antiretroviral drugs in a lean and high fat/sucrose diet rat model of obesity419Statins in the treatment of non-alcoholic steatohepatitis (NASH). 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V Garcia-Martinez, C Lopez Sanchez, W Hamed, 2016

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