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NUCLEIC ACID APTAMERS AND ITS USES AGAINST LYMPHOCYTE ACTIVATION GAS 3 (LAG-3)
NUCLEIC ACID APTAMERS AND ITS USES AGAINST LYMPHOCYTE ACTIVATION GAS 3 (LAG-3)
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机译:核酸适体及其抗淋巴细胞活化气体3(LAG-3)的应用
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摘要
Nucleic acid aptamers capable of binding to lymphocyte activation gene 3 (LAG-3) and uses thereof for modulating immune responses. Such aptamers may comprise a G-rich motif, for example, GX1GGGX2GGTX3A (SEQ ID No: 1), in which each of X1 and X2 are independently G, C, or absent, and X3 is T or C, or L-(G)n-L′, in which n is an integer of 5-9 inclusive, and L and L′ are nucleotide segments having complementary sequences. Also provided herein are multimeric nucleic acid aptamers containing a backbone moiety, which comprises a palindromic sequence.
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机译:能够结合淋巴细胞激活基因3(LAG-3)的核酸适体及其用于调节免疫应答的用途。此类适配子可包含富含G的基序,例如GX1GGGX2GGTX3A(SEQ ID No:1),其中X1和X2中的每一个独立地为G、C或缺失,X3为T或C,或L-(G)n-L′,其中n为5-9(含5-9)的整数,L和L′为具有互补序列的核苷酸片段。本文还提供了包含骨架部分的多聚核酸适体,其包含回文序列。
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