Nucleic acid aptamers capable of binding to lymphocyte activation gene 3 (LAG-3) and uses thereof for modulating immune responses. Such aptamers may comprise a G-rich motif, for example, GX1GGGX2GGTX3A (SEQ ID No: 1), in which each of X1 and X2 are independently G, C, or absent, and X3 is T or C, or L-(G)n-L′, in which n is an integer of 5-9 inclusive, and L and L′ are nucleotide segments having complementary sequences. Also provided herein are multimeric nucleic acid aptamers containing a backbone moiety, which comprises a palindromic sequence.
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机译：能够与淋巴细胞活化基因3（LAG-3）结合的核酸适体及其用于调节免疫应答的用途。这种适体可包括富含G的基序，例如，Gx 1 gggx 2 ggtx 3 a（SEQ ID NO：1），其中x 1 和x 2 是独立的g，c或不存在，x 3 是t或c，或l-（ g） n -l'，其中n是5-9的整数，L和L'是具有互补序列的核苷酸段。本文还提供了含有骨架部分的多聚体核酸适体，其包含回文序列。
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