METHOD AND KIT FOR TESTING DRUG HYPERSENSITIVITY REACTIONS CAUSED BY SULFONAMIDE DERIVATIVE-BASED ANTIEPILEPTIC DRUG, AND USE OF KIT

摘要

The present invention provides a method for assessing the risk of drug hypersensitivity reactions caused by a sulfonamide derivative-based antiepileptic drug in an individual in need of such an assessment, comprising a step of detecting the presence of HLA-B alleles in a sample obtained from the individual, wherein the presence of the alleles indicates that the individual has an increased risk of drug hypersensitivity reactions caused by the sulfonamide derivative-based antiepileptic drug. The present invention also provides a method for treating or reducing the incidence of such drug hypersensitivity reactions. Also provided are a test kit for assessing the risk of a patient developing drug hypersensitivity reactions caused by a sulfonamide derivative-based antiepileptic drug, comprising a kit for determining specific HLA alleles, and use of the test kit in assessing the risk of a patient developing drug hypersensitivity reactions caused by a sulfonamide derivative-based antiepileptic drug.