A 27-Year Retrospective Study of Cutaneous Adverse Drug Reaction on In-patients at Tongji Hospital

摘要

Objective:To investigate the prevalence profile of cutaneousadverse drug reactions(CADRs)on in-patients in one of the largest comprehensive hospitals in central Chinaduring the past27years.
　　Method:Aretrospectiveanalysis was carried out on the clinical dataofall in-patients withCADRs in Tongji Hospital,Tongji Medical College,Huazhong University of ScienceandTechnology from May1985toApril2012.
　　Results:Atotal of110,553in-patients wereadmittedat Tongji Hospital from May1985toApril2012.Among them,777cases were diagnosedas CADRs,accounted for0.70％.Maximumpatients belonged to theage group of31-40years,followed by21-30and0-10years.The mostcommon type of CADRs in our datawas maculopapular eruption(509cases,65.46％)followedby erythemamultiforme(88cases,11.34％),fixed drug eruption(75cases,9.66％),and urticaria(63cases,8.12％).Atotal of22variations,including162varieties,of causative drugs wereinvolved in this survey,which includingantibiotics,antiepileptic drugs,antipyreticsandanalgesics,anti-gout drugs,anti-tuberculosis drugs,immunomodulatoryand immunosuppressiveagents,xenogeneic serum preparations,vaccines,traditional Chinese medicines(TCMs),andothers.Among these causativeagents,antibioticsaccounted for48.39％,which were followed byantiepileptic drugs,antipyreticsandanalgesics.Maculopapular eruptionsand erythemamultiforme were mainly caused by these drugs.Fixed drug eruptions were mainly due tosulfonamides,followed byantipyreticsandanalgesics.32patients(4.12％)with severe CADRs(SCADRs)wereanalyzed in our data.They were mainly caused byantiepileptic drugs(18cases,56.25％)andanti-gout drugs(5cases,15.625％).Among the culprit drugs,TCM wasoutstandingly listed for being responsible to3cases with Stevens-Johnson syndrome(SJS).Finally,comparativeanalysis to constituent ratio in every9-year period showed that theprevalence of different kinds of drug changed in these periods in this study.Overall,moreandmore CADRsappeared with the time but the rate ofallergicantibiotics decreased graduallyduring the study period.Although the incidences of CADRs induced by cephalosporinsandquinolones increased slightly,the incidences of CADRs caused by penicillinsand sulfonamideswere decreased markedly during recent years.Furthermore,the incidences of CADRs induced byother kinds of drug,especiallyantiepileptic drugs,anti-gout drugsand TCM,were distinctlyincreased.
　　Conclusions:In our study,the most common type of CADRs was maculopapular eruptionsfollowed by erythemamultiforme,fixed drug eruption,and urticaria.Antibiotics was the mainoffendingagent followed byantiepileptic drugs,antipyreticsandanalgesics.Among theantibiotics,the incidence of CADRs induced by penicillinand sulphonamide had decreased toacertain extent,the incidence of CADRs caused by cephalosporinand quinolone increased inrecent years.SCADRs were mainly caused byantiepileptic drugsandanti-gout drugs,especiallycarbamazepineandallopurinol.Among other culprit drugs,TCM was outstandingly listed forincreasing rapidlyand being responsible for some cases with SJS.It is suggested that we have topay moreattention to it.

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封面

声明

目录

List of abbreviations

英文摘要

Introduction

Methodology

Results

Discussion

Conclusion

参考文献

A review of literature on cutaneous adverse drug reactions

参考文献

致谢