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HIGHLY SENSITIVE PLATFORM TO CHARACTERIZE EXTRACELLULAR VESICULAR BIOMARKERS FOR CANCER IMMUNOTHERAPY
HIGHLY SENSITIVE PLATFORM TO CHARACTERIZE EXTRACELLULAR VESICULAR BIOMARKERS FOR CANCER IMMUNOTHERAPY
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机译:用于癌症免疫治疗的细胞外囊泡生物标记物的高灵敏度表征平台
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摘要
Methods and systems for characterizing extracellular vesicular biomarkers using a biochip with gold nanoparticles. The biochip includes a glass surface, a gold film layer on the glass surface, a plurality of gold nanoparticles coupled to the gold film layer, and a plurality of biotinylated antibodies coupled to the gold nanoparticles. In some implementations, the gold film layer of the biochip is coated with polyethylene glycol (PEG). The biotinylated antibodies are selected to capture specific types of extracellular vesicles. PD-L1/PD-1 proteins and RNAs in extracellular vesicles were characterized for cancer immunotherapy.
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