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NEUTRALISATION OF HUMAN CYTOKINS WITH MEMBRANGE-BASED, NON-SIGNALIZING ANTI-CYTOKIN BINDERS WITH IMMUNE CELL EXPRESSION
NEUTRALISATION OF HUMAN CYTOKINS WITH MEMBRANGE-BASED, NON-SIGNALIZING ANTI-CYTOKIN BINDERS WITH IMMUNE CELL EXPRESSION
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机译:用基于膜的非信号性抗细胞因子粘合剂中和具有免疫细胞表达的人细胞因子
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摘要
Transgenic T cells and vectors for making transgenic T cells are described. The vectors can include a nucleic acid encoding a membrane-bound anti-IL6 (mb-alL6) single chain variable fragment (scFv), and the transgenic T cells can express mb-alL6. The transgenic T cells are useful for suppressing proliferation of IL-6-dependent cells, reducing IL-6 concentration, or both. In one embodiment, the vector is a bicistronic construct encoding the mb-alL6 and an anti-CD19-41 BB-003ζ chimeric antigen receptor (CAR). In another embodiment, an anti-IL-6 scFv can be linked to a 41 BB and 003ζ domains to form an anti-IL-6 CAR. The transgenic T cells expressing said constructs can reduce the linker risk of cytokine release syndrome (CRS) in cancer patients being treated with CAR T cell or for the treatment of autoimmune diseases and inflammatory diseases in which cytokines are involved in pathogenesis.
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