首页>
外国专利>
G9A INHIBITION DECREASES STRESS-INDUCED AND DEPENDENCE-INDUCED ESCALATION OF ALCOHOL DRINKING
G9A INHIBITION DECREASES STRESS-INDUCED AND DEPENDENCE-INDUCED ESCALATION OF ALCOHOL DRINKING
展开▼
机译:G9A抑制降低了应力诱导和依赖性诱导的酒精饮用升级
展开▼
页面导航
摘要
著录项
相似文献
摘要
Provided are methods for reducing substance consumption by subjects. In some embodiments, the presently disclosed methods include administering to a subject in need thereof a composition that includes an effective amount of an inhibitor of an EHMT2/G9A biological activity. In some embodiments, the inhibitor of an EHMT2/G9A biological activity is a small molecule inhibitor, a nucleic acid-based inhibitor, and anti-EHMT2/G9A antibody or a fragment or derivative thereof, or any combination thereof. Also provided are methods for reducing relapse vulnerability in subjects that have Alcohol Use Disorder (AUD) and/or another substance use disorder. In some embodiments, the presently disclosed methods further include administering at least one additional therapy to subjects, including but not limited to behavioral therapies such as cognitive behavioral therapies.
展开▼