METHOD FOR PREDICTING PREMATURE RUPTURE OF MEMBRANES IN THE PERIOD FROM 22 TO 28 WEEKS OF GESTATION

摘要

FIELD: medicine.;SUBSTANCE: invention relates to medicine, namely to obstetrics. In pregnant women at a gestational age of 22-28 weeks, the relative abundance of bacteria of the genus Lactobacillus and Staphylococcus, expressed as a percentage (%), is determined in the vaginal microbiome, and the probability of premature rupture of the membranes is calculated within 28 weeks. pregnancy p according to the formula. If the p value is 57.42% or more, the development of premature rupture of the membranes is predicted in the period from 22 to 28 weeks of pregnancy.;EFFECT: method allows increasing the accuracy and specificity of prognosis of PRM at the preclinical stage, when the membranes have not yet ruptured, and due to this, the possibility of timely optimization of pregnancy management tactics and improvement of perinatal outcomes.;1 cl, 3 ex, 1 dwg