Non-catalytic electrochemical deuteration method using heavy water as a deuterium source

摘要

PROBLEM TO BE SOLVED: To disclose a non-catalytic electrochemical deuteration method using heavy water as a deuterium source. The present invention relates to a non-catalytic electrochemical dehydrogenation method using heavy water as a heavy hydrogen source, in which an electrolyte, an organic substance containing an ethylene bond or an acetylene bond, heavy water, and an organic solvent are added to a reactor as an electrode material. Using carbon felt, an electrolytic reaction is carried out by applying a DC voltage of 4 to 8 V in an inert gas atmosphere to purify the reaction product to obtain a dehydrogenation product. In the present invention, heavy water is used as a deuterium source, inexpensive and easily available carbon electrode materials are used as a cathode and an anode, and DC electrolysis is performed in an organic solvent to obtain a deuterated product. No optional transition metal catalyst is required, the reaction yield is 50-90% and the deuteration rate is over 90%. Since the use of transition metals is avoided, the reaction is suitable for modifying drug molecules at a later stage, and at the same time, the reaction pathway is different from the transition metal-catalyzed reaction process, which is different from the transition metal-catalyzed dehydrogenation reaction. Chemical selectivity can be achieved.