COMPOSITIONS AND METHODS FOR TCR REPROGRAMMING USING FUSION PROTEINS AND PD-1 ANTIBODIES

摘要

The present disclosure provides T-cell (receptor) fusion proteins (TFPs) comprising binding domains targeting various antigens associated with a disease or nucleic acid molecules encoding such TFPs. The present disclosure also provides anti-PD-1 antigen-binding proteins or a fragment thereof, as well as nucleic acids molecules encoding the anti-PD-1 antigen-binding proteins. The present disclosure further provides modified T cells expressing such TFPs or antigen-binding protein or fragment thereof, and methods of regulating T cells or treating patients using such constructs or modified T cells.