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17 β- RNAi agent for inhibiting expression of hsd13 type (hsd17b13), its composition and usage

机译:17β-RNAi试剂抑制HSD13型(HSD17B17)的表达,其组成和使用

摘要

This disclosure is β- Hydroxysteroid dehydrogenase type 13 (hsd17b13 or 17). β- The present invention relates to an RNAi agent capable of inhibiting gene expression.Disclosed is a pharmaceutical composition comprising hsd17b13 RNAi and its use.The hsd17b13 RNAi agent disclosed herein may be associated with the target ligand and may facilitate delivery to cells including hepatic parenchymal cells.Delivery of hsd17b13 RNAi agents in vivo provides an inhibition of hsd17b13 gene expression.Non alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), liver fibrosis Hsd17b13 related diseases and disorders may be used in treating treatment of hsd17b13 related diseases and disorders including alcoholic or non-alcoholic fatty liver disease.
机译:本公开是β-羟类脱氢酶13型(HSD17B13或17)。 β-本发明涉及一种能够抑制基因表达的RNAi剂。将包含HSD17B13 RNAi的药物组合物及其使用。本文公开的HSD17B13 RNAi剂可以与靶配体相关,并且可以促进递送给包括肝实质的细胞 体内HSD17B13 RNAi试剂的细胞提供了HSD17B13基因表达的抑制。含酒精脂肪肝疾病(NAFLD),非酒精脂肪性肝炎(NASH),肝纤维化HSD17B13相关疾病和病症可用于治疗HSD17B13相关的治疗方法 包括酒精或非酒精脂肪肝病在内的疾病和疾病。

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