Disclosed are oral wash compositions for collection of analyte in oral fluid sample. The oral wash includes an internal tracer, which can be directly detected by a mass-spec-based analytical method such as LC-MS, GC-MS, CE-MS, HPLC-MS/MS, HPLC-TOF or MALDI-TOF assay, along with all the other analytes being tested in the collected oral fluid. The oral wash optionally includes agents to induce salivation, maintain oral wash integrity at room temperature, and stabilize the collected oral fluid, and one or more dyes. The oral wash is used to collect saliva from the oral cavity, in order to determine the presence of an analyte in the saliva. The method includes rinsing the oral cavity with the oral wash for a period of time effective to stimulate saliva production, collecting the resulting fluid and subjecting the resulting fluid to a mass-spec-based analytical method to detect the presence of an analyte in the sample.
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