The present invention relates to a method of determining the status of high-grade serous ovarian carcinoma (HGSOC) in a subject, the method comprising: providing a sample obtained from the subject; and detecting the presence of HGSOC biomarkers in the sample, wherein the method comprises detecting the presence of: a differentiated cell type; a KRT17 Cluster cell type; an epithelial-mesenchymal transition (EMT) cell type; a cell cycle cell type; and a ciliated cell type; wherein the level of the biomarkers is used to determine the fraction of EMT cells in the high-grade serous ovarian carcinoma in the subject. The invention further relates to associated kits, use and methods of treatment.
展开▼
