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Complement factor H gene knockout rat as a model of C3 glomerulopathy
Complement factor H gene knockout rat as a model of C3 glomerulopathy
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机译:补体因子H基因敲除RAT作为C3肾小球疗法模型
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摘要
Methods for producing and using rat cells and rats including deactivated CFH loci, and such rat cells and rats are provided.Rats with an inactivated CFH locus model C3 glomerulopathy (C3G).A method for using such rats including an inactivated CFH locus is provided to assess in vivo efficacy of the putative C3G therapeutic agent.The present invention provides gene modified rats, including, for example, an inactivated endogenous CFH locus.
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