首页> 外国专利> COMPLEMENT FACTOR H GENE KNOCKOUT RAT AS A MODEL OF C3 GLOMERULOPATHY

COMPLEMENT FACTOR H GENE KNOCKOUT RAT AS A MODEL OF C3 GLOMERULOPATHY

机译：补体因子H基因敲除大鼠作为C3肾病模型

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摘要

Rat cells and rats comprising an inactivated Cƒh locus and methods of making and using such rat cells and rats are provided. The rats comprising an inactivated Cƒh locus model C3 glomerulopathy (C3G). Methods are provided for using such rats comprising an inactivated Cƒh locus to assess in vivo efficacy of putative C3G therapeutic agents.

机译：提供了包含灭活的 C ƒ h 基因座的大鼠细胞和大鼠，以及制备和使用这种大鼠细胞和大鼠的方法。包含灭活的 C ƒ h 基因座模型C3肾小球病（C3G）的大鼠。提供了使用这样的包含灭活的 C ƒ h 基因座的大鼠来评估推定的C3G治疗剂的体内功效的方法。 展开▼

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公开/公告号WO2020056122A1

专利类型

公开/公告日2020-03-19

原文格式PDF

申请/专利权人 REGENERON PHARMACEUTICALS INC.;
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申请/专利号WO2019US50792

发明设计人 DEVALARAJA-NARASHIMHA KISHOR;LEE JEFFREY D.;MORTON LORI;
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申请日2019-09-12

分类号A01K67/027;

国家 WO

入库时间 2022-08-21 11:12:38

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5. COMPLEMENT FACTOR H GENE KNOCKOUT RAT AS A MODEL OF C3 GLOMERULOPATHY [P] . EP3849304A1 . 2021-07-21

机译：补体因子H基因敲除RAT作为C3肾小球病的模型

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